| product name |
: |
Suramin Hexasodium Salt , ACS – sterilized |
| product origin |
: |
100% made in European Union (according to USP, EUP, ECHA-REACH) |
| purity grade |
: |
>99.99+% min. (raw virgin matter, ultra-pure) |
| use |
: |
lab. / tech / pharma / bio-research |
| product code |
: |
EA61707 |
| C.A.S. number |
: |
129-46-4 |
| MDL |
: |
MFCD00210217 |
| EINECS |
: |
204-949-3 |
| ID PubChem |
: |
24277738 |
| NACRES |
: |
NA.25 |
| formula molecular |
: |
C51H34N6Na6O23S6 |
| molecular weight |
: |
1429.16 |
| assay (unspecified) |
: |
>99.99% to <101.5% |
| quality level |
: |
200 |
| sensitivity & storage |
: |
store in cool place; keep container tightly closed in a dry and well-ventilated place *5 °C/25 °C |
| solubility |
: |
in water and saline (turbidity) <15% (H2O >10 mg/ml); sparingly soluble in 95% bethanol |
| appearance (color) |
: |
white to pale cream |
| form |
: |
powder |
| general description |
: |
Suramin is a antiparasitic drug , which blocks endothelial cell proliferation and increases |
| x |
: |
tyrosine phosphorylation of many signalling proteins; associated with urticaria, paresthesias, |
| x |
: |
vomitino and neurologic toxicity; is used also to treat trypanosomiasis and onchocerciasis; to |
| x |
: |
functions as an heparanase inhibitor and also exhibits anti-AIDS (acquired immunodeficiency syndrome) property ; also studied for the treatment of autism . |
| x |
: |
Suramin Sodium salt has been used : |
| applications |
: |
– as a potent blocker of rat P2Y2 purinergic receptor ; |
| x |
: |
– to study it’s effects on short circuit current (lsc) acress strial marginal cells ; |
| x |
: |
– to show it’s effects on initial burst of glial activity ; |
| x |
: |
– to assess it’s neuroprotective potential in rats ; |
| x |
: |
– as a purinoceptor inhibitor, to explore the mechanism of action of extracellular adenosine |
| x |
: |
– triphosphate (eATP) . |
| x |
: |
Suramin Sodium has been observed as a potent inhibitor of melanoma HPA (heparanase) and |
| x |
: |
tumor cell metastasis; inhibition of NAD+-dependent deacetylase SIRT1 with an IC50 of 2.6 ?M |
| x |
: |
along with SIRT5 has also been observed; Suramin Sodium has been recorded to antagonize |
| x |
: |
EDG–3 (S1P3) selectively; Suramin Sodium is an inhibitor of A cyclase, FGF-1, FGF-2, IL-1, IL-4, |
| x |
: |
PDGF, PC-PLD, PKC, SH-PTP, TERT, TGF beta 1, Topo I, Topo II and VEGF ; it is used as a G |
| x |
: |
protein uncoupler and inhibitor of PDGF, EGF, TGF-β, SIRT1 and SIRT5; it also blocks calmodulin |
| x |
: |
binding to recognition sites and G protein coupling to G protein-coupled receptors; increases |
| x |
: |
open probability of ryanodine receptor (RyR) channels ; anticancer and antiviral agent |
| notes |
: |
store in cool place ; keep container tightly closed in a dry and well-ventilated place *(1) ; |
| x |
: |
keep away from strong oxidizing agents *(1) ; |
| shelf lifex |
: |
2 (two) years from production date (sealed package), * shipped in ambient (1) . |
| packaging/transport |
: |
special for chemicals transport (according to IATA / ADR / ECHA-REACH rules / int.l laws). |
| certifications |
: |
C.O.A., MSDS, GMP, API, USP, EUP, ECHA-REACH, ORIGIN, etc… |
|
: |
(originals will be delivered with good , and copies after confirmed order ) |
