Suramin Hexasodium Salt , ACS - sterilized

Suramin Hexasodium Salt , ACS – sterilized

Suramin Hexasodium Salt , ACS >99.99+% min. (raw virgin matter, ultra-pure, sterilized)

Description

Suramin Hexasodium Salt , ACS – sterilized

product name : Suramin Hexasodium Salt , ACS – sterilized
product origin : 100% made in European Union (according to USP, EUP, ECHA-REACH)
purity grade : >99.99+% min. (raw virgin matter, ultra-pure)
use : lab. / tech / pharma / bio-research
product code : EA61707
C.A.S. number : 129-46-4
MDL : MFCD00210217
EINECS : 204-949-3
ID PubChem : 24277738
NACRES : NA.25
formula molecular : C51H34N6Na6O23S6
molecular weight : 1429.16
assay (unspecified) : >99.99% to <101.5%
quality level : 200
sensitivity & storage : store in cool place; keep container tightly closed in a dry and well-ventilated place *5 °C/25 °C
solubility : in water and saline (turbidity) <15% (H2O >10 mg/ml); sparingly soluble in 95% bethanol
appearance (color) : white to pale cream
form : powder
general description : Suramin is a antiparasitic drug , which blocks endothelial cell proliferation and increases
x : tyrosine phosphorylation of many signalling proteins; associated with urticaria, paresthesias,
x : vomitino and neurologic toxicity; is used also to treat trypanosomiasis and onchocerciasis; to
x : functions as an heparanase inhibitor and also exhibits anti-AIDS (acquired immunodeficiency syndrome) property ; also studied for the treatment of autism .
x : Suramin Sodium salt has been used :
applications : – as a potent blocker of rat P2Y2 purinergic receptor ;
x : – to study it’s effects on short circuit current (lsc) acress strial marginal cells ;
x : – to show it’s effects on initial burst of glial activity ;
x : – to assess it’s neuroprotective potential in rats ;
x : – as a purinoceptor inhibitor, to explore the mechanism of action of extracellular adenosine
x : – triphosphate (eATP) .
x : Suramin Sodium has been observed as a potent inhibitor of melanoma HPA (heparanase) and
x : tumor cell metastasis; inhibition of NAD+-dependent deacetylase SIRT1 with an IC50 of 2.6 ?M
x : along with SIRT5 has also been observed; Suramin Sodium has been recorded to antagonize
x : EDG–3 (S1P3) selectively; Suramin Sodium is an inhibitor of A cyclase, FGF-1, FGF-2, IL-1, IL-4,
x : PDGF, PC-PLD, PKC, SH-PTP, TERT, TGF beta 1, Topo I, Topo II and VEGF ; it is used as a G
x : protein uncoupler and inhibitor of PDGF, EGF, TGF-β, SIRT1 and SIRT5; it also blocks calmodulin
x : binding to recognition sites and G protein coupling to G protein-coupled receptors; increases
x : open probability of ryanodine receptor (RyR) channels ; anticancer and antiviral agent
notes : store in cool place ; keep container tightly closed in a dry and well-ventilated place *(1) ;
x : keep away from strong oxidizing agents *(1) ;
shelf lifex : 2 (two) years from production date (sealed package), * shipped in ambient (1) .
packaging/transport : special for chemicals transport (according to IATA / ADR / ECHA-REACH rules / int.l laws).
certifications : C.O.A., MSDS, GMP, API, USP, EUP, ECHA-REACH, ORIGIN, etc…
: (originals will be delivered with good , and copies after confirmed order )

Related Products